I recently decided to encrypt my Xoom tablet. The process went smoothly (full power, plugged in the whole time, took about an hour) but since the encryption, it seems like my battery life has decreased. With moderate usage, I used to get close to two days worth of usage before the encryption, but now my battery usage meter has me at 15% after 23 hours.
I found this thread on the Motorola Owners' Forums but that is about it.