When I change my phone font to "Large", the screen layout is messed up. The screenshots how that the right margin is increased. The left screenshot shows the normal margins. The right screenshot shows how the Google Now field, the camera and the Settings icon are bumped to the left. (I drew the blue arrows in a paint program.)
If I change the font to "Normal", then back to "Large", the increased margin does not appear right away. But, when I have the font setting on "Large" and then exit a phone call or message or an app, the margin gets increased.
Phone: Moto E 2nd generation with 4G LTE Android version 5.1
iNaturalist, Audubon Birds, Clipboard History, eBird, Excel, GPS Coordinates, Overdrive, Simplenote, Yahoo Mail, Zinio
Along with the ones that came with the phone: Google Calendar, Camera, Chrome, etc.
No alternate launcher. Multiple windows is not enabled.