Bypassing per site cache:
Enter the above code in the browser address bar and hit Enter key. This will fetch all the contents from the server instead of picking the elements cached in your browser(thus bypassing the browser cache).
Bypass Cache data for all websites(Global cache)
Settings > Privacy > CLEAR BROWSING DATA
Select the "Cache" Checkbox (and other options like Browser data, Cookies, Password etc if you want) and select "Clear".
F5 will cause the browser to throw out the cache and request new contents from the server, the server may ignore the
no-cache header and serve a server-side cached page. Thus, even
F5 may return an old version of the page if the server ignores the no-cache header.
Browsing through incognito mode disables history and cache. So you can visit any site through incognito mode to request fresh content everytime.
For more interesting discussion on the what does
F5 or force refresh does,
Read this SO post, What requests do browsers' “F5” and “Ctrl + F5” refreshes generate?