Is it safe for me to remove the stock email and calendar applications on from Cyanogenmod ROM? I'm using Gmail and Google Calendar so I don't have need for the stock ones. I could simply disable them but if I removed them entirely, I might be able to save a bit on space on my system partition.
YES, you can delete the stock Email (Email.apk) and stock Calendar (Calendar.apk, CalendarProvider.apk) app. For a list of other apps you can delete on CyanogenMod, see the expandable list at the bottom of the CM wiki.
I'm not so sure for AOSP though.