I have a Motorola Droid on Verizon, and a lot of times when I unlock it, my homescreen will be blank; no icons, no widgets. Nothing in my app tray, either. I have to wait for about a minute for everything to load before I can launch anything (unless the app I just used was one of the 6 most recent, in which case I can long-press Home with no problem).
I think the problem is a lack of memory; my phone is probably auto-killing the launcher constantly. When I use an option on a third-party launcher to avoid closing the launcher, I don't have this problem anymore, but I'll often be kicked out of the app in the foreground!
Now for my system details... I'm currently running Cyanogenmod 6.1, but it was doing this before I rooted (in fact, I mainly rooted because I thought it would fix the problem). I'm using ADW.Launcher as well, but again, it was doing this with the stock launcher. I'm also not using any task killer apps.
Has anybody else had this problem? I haven't talked to any other Android users who have mentioned this.